PROLINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

Overview

Proline is an amino acid, or a building block for protein. The body can make proline on its own, but it is also consumed in the diet. A typical diet contains about 5 grams of proline daily. The primary sources are protein-rich foods including meat, fish, and dairy. Proline can also be taken as a supplement.

Proline is used for skin healing, especially in people who have problems keeping enough proline in the body. It is also used for other conditions, but there is no good scientific evidence to support any of these uses.

In medicine, proline is used as a stabilizer to help some prescription products last longer.

How does it work ?

The body uses proline to make proteins, such as collagen. Collagen is found in the skin, bones, and joints. Proline is also involved in the general function of cells.

The body uses proline to make proteins, such as collagen. Collagen is found in the skin, bones, and joints. Proline is also involved in the general function of cells.

Uses & Effectiveness ?

Insufficient Evidence for

  • Athletic performance. Teens who eat more proline in the diet don't seem to be any more physically fit than teens who eat less proline.
  • Low bone mass (osteopenia). Eating more proline in the diet doesn't seem to protect against osteopenia.
  • Weak and brittle bones (osteoporosis). Eating more proline in the diet doesn't seem to protect against osteoporosis.
  • Fractures.
  • Fatigue.
  • Insomnia.
  • Infections.
  • Wrinkles.
  • Wound healing.
  • Skin ulcers.
  • Defects in proline metabolism.

More evidence is needed to rate the effectiveness of proline for these uses.

Side Effects

When taken by mouth: Proline is LIKELY SAFE when taken by mouth in food amounts. There isn't enough reliable information to know if proline is safe when used in larger amounts as medicine or what the side effects might be.

When applied to the skin: There isn't enough reliable information to know if proline is safe or what the side effects might be.

Special Precautions and Warnings

When taken by mouth: Proline is LIKELY SAFE when taken by mouth in food amounts. There isn't enough reliable information to know if proline is safe when used in larger amounts as medicine or what the side effects might be.

When applied to the skin: There isn't enough reliable information to know if proline is safe or what the side effects might be. Pregnancy and breast-feeding: There isn't enough reliable information to know if proline is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to the amounts found in foods.

Children: Proline is LIKELY SAFE when taken by mouth in food amounts.

Interactions ?

We currently have no information for PROLINE overview.

Dosing

The appropriate dose of proline depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for proline. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2020.

PROLINE: Overview, Uses, Side Effects, Precautions, Interactions, Dosing and Reviews (2024)

FAQs

What is the overview of proline? ›

Overview. Proline is an amino acid, or a building block for protein. The body can make proline on its own, but it is also consumed in the diet. A typical diet contains about 5 grams of proline daily.

Does proline have side effects? ›

Proline supplementation can have several risks and side effects. One potential risk is the impairment of amino acid transport, as high intake of proline may disrupt the distribution of amino acids among tissues and their absorption in the gut and kidneys .

What does proline interact with? ›

The aromatic–proline interaction is enthalpic, consistent with its description as a CH/π interaction. Proline–aromatic sequences can also promote cis-prolyl bonds, either through interactions of the aromatic ring with the preceding cis-proline or with the Hα prior to cis-proline.

What does proline do for your body? ›

L-proline is a proteinogenic amino acid crucial for collagen synthesis that supports skin elasticity and healing, joint cushioning through cartilage repair, muscle preservation in endurance athletes, and connective tissue recovery from injuries, addressing deficiencies caused by poor diets, chronic illness, or ...

What are the hazards of proline? ›

Skin: May cause skin irritation. Ingestion: May cause irritation of the digestive tract. The toxicological properties of this substance have not been fully investigated. Inhalation: May cause respiratory tract irritation.

What is proline responsible for? ›

Proline is the key component of collagen and extracellular matrix by acting as a 'stress substrate' in stress conditions through the proline cycle. This amino acid can also modulate some of the bioenergetics and tumorigenic processes [63].

Is proline good or bad for you? ›

Proline is involved in processes such as protein synthesis, immune regulation and tissue development. Like lysine, it is also essential for the production of collagen, the richest protein in the human body, highlighting its importance for skin, joint and bone health.

Who should not take amino acids? ›

BCAAs may interfere with blood glucose levels during and after surgery. You may also be at increased risk if you have chronic alcoholism or branched-chain ketoaciduria. Also, avoid using BCAAs if you are pregnant or breastfeeding.

What does proline do in human? ›

Proline plays important roles in protein synthesis and structure, metabolism (particularly the synthesis of arginine, polyamines, and glutamate via pyrroline-5-carboxylate), and nutrition, as well as wound healing, antioxidative reactions, and immune responses.

What foods are high in proline? ›

Proline is found in collagen-rich foods like bone broth and gelatin, fish, meat, and dairy foods.

What happens if you have too much proline? ›

Some individuals with hyperprolinemia type I exhibit seizures, intellectual disability, or other neurological or psychiatric problems. Hyperprolinemia type II results in proline levels in the blood between 10 and 15 times higher than normal, and high levels of a related compound called pyrroline-5-carboxylate.

When to take proline? ›

Recommended daily intake for L-Proline 500 mg: as a dietary supplement, adults take 1-2 times daily 1-2 veg. capsules. Preferable taken on an empty stomach or in between meals. Don't exceed the (recommended) dosage.

Does proline raise blood pressure? ›

In fully-adjusted model, individuals in the highest tertile for proline intake had an increased risk of incident hypertension than those in the lowest one (OR: 1.45; 95%CI: 1.06-1.97; p for trend: . 017).

Does proline increase collagen? ›

Both proline and hydroxyproline are vital for collagen biosynthesis, structure, and strength. Their cyclic structure constrains the rotation of the polypeptide collagen chain, creating and strengthening the helical characteristic of the molecule (7).

Is proline good for hair growth? ›

So, the intake of proline-rich collagen should give your body what it needs to grow hair and slow down or prevent androgenetic alopecia, which is also known as female- or male-pattern baldness. Thinning hair – Proline hydroxylation and O-glycosylation (or HRGPs) are essential for driving root hair growth.

What is the significance of proline? ›

Apart from acting as osmolyte for osmotic adjustment, proline contributes to stabilizing sub-cellular structures (e.g., membranes and proteins), scavenging free radicals and buffering cellular redox potential under stress conditions.

What is special about the amino acid proline? ›

Proline is special because it is the only amino acid whose side chain connects to its amino acid backbone twice. It connects once to the central carbon and again to the nitrogen of the amino group. This double connection creates a unique ring structure with a secondary nitrogen.

What is the unique feature of proline? ›

Proline is a nonessential amino acid with a unique structure. Owing to the nitrogen group binding the alpha carbon to form a five-membered ring, proline lacks the primary amine group present in other amino acids and instead has a secondary amine.

What is unusual about proline? ›

Proline is unusual in that it is heterocyclic, and thus is the only natural amino acid that contains a secondary amine group. Only the L-enantiomer is found in nature.

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